二氧化碳描记术增强了程序镇静期间呼吸事件的监测：一项荟萃分析。
Capnography enhances surveillance of respiratory events during procedural sedation: a meta-analysis.
机构信息
Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
J Clin Anesth. 2011 May;23(3):189-96. doi: 10.1016/j.jclinane.2010.08.012. Epub 2011 Apr 14.
STUDY OBJECTIVE
To determine if capnography, in addition to standard monitoring, identified more respiratory complications than standard monitoring alone.
DESIGN
Meta-analysis.
SETTING
University medical center.
MEASUREMENTS
The electronic databases PubMed, CINAHL, and Cochrane Library (Cochrane Reviews, CENTRAL) were searched for studies published between 1995-2009 reporting adverse respiratory events during procedural sedation and analgesia (PSA) with clearly defined end-tidal carbon dioxide threshold, adult population, clear study design, P-value calculation, similar outcome and predictor variable definitions, and binary independent and dependent variable raw data. Five such studies were evaluated independently. A meta-analysis of these studies was performed.
MAIN RESULTS
During PSA, cases of respiratory depression were 17.6 times more likely to be detected if monitored by capnography than cases not monitored by capnography (95% CI, 2.5-122.1; P < 0.004).
CONCLUSION
End-tidal carbon dioxide monitoring is an important addition in detecting respiratory depression during PSA.
研究目的
确定二氧化碳描记术（capnography）与标准监测相比，是否能比标准监测单独检测出更多的呼吸并发症。
设计
荟萃分析。
地点
大学医疗中心。
测量方法
电子数据库 PubMed、CINAHL 和 Cochrane Library（Cochrane 评价、CENTRAL），搜索 1995-2009 年发表的研究报告，报告在程序镇静和镇痛（PSA）期间，使用明确界定的呼气末二氧化碳阈值、成人人群、明确的研究设计、P 值计算、相似的结局和预测变量定义以及二进制独立和依赖变量原始数据，发生了不良呼吸事件。对 5 项这样的研究进行了独立评估。对这些研究进行了荟萃分析。
主要结果
在 PSA 期间，如果使用二氧化碳描记术监测，呼吸抑制的病例比未使用二氧化碳描记术监测的病例更有可能被检测到（95%CI，2.5-122.1；P<0.004）。
结论
在 PSA 期间检测呼吸抑制时，呼气末二氧化碳监测是一种重要的附加手段。
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