Stegmüller Judith, Bonni Azad
F1000 Biol Rep. 2010 May 24;2:38. doi: 10.3410/B2-38.
The ubiquitin proteasome system (UPS) has drawn tremendous attention in the field of neuroscience. In recent years, we have gained insights into UPS-dependent mechanisms in brain development and disease. Several interesting studies over the past two years have highlighted the role of distinct E3 ubiquitin ligases in neurogenesis. Here, we will review the major findings in these studies and discuss their implications.
泛素蛋白酶体系统（UPS）在神经科学领域引起了极大关注。近年来，我们对大脑发育和疾病中依赖UPS的机制有了深入了解。过去两年的几项有趣研究突出了不同E3泛素连接酶在神经发生中的作用。在此，我们将回顾这些研究中的主要发现并讨论其意义。
