Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei.
Oral Dis. 2011 Jan;17(1):95-101. doi: 10.1111/j.1601-0825.2010.01711.x.
The objective of this study was to test the efficacy of three different treatment modalities on the reduction of serum anti-gastric parietal cell autoantibody (GPCA) level in GPCA-positive oral lichen planus (OLP) patients.
Of 147 GPCA-positive OLP patients, 100 were treated with levamisole plus vitamin B12, 10 with vitamin B12 only and 37 with levamisole only. The serum GPCA levels in 147 OLP patients were measured at baseline and after treatment.
Treatment with levamisole plus vitamin B12 for a period of 2-50 months and treatment with vitamin B12 only for a period of 4-44 months could effectively reduce the high serum GPCA level to undetectable level in 100 and 10 OLP patients, respectively. However, treatment with levamisole only for a period of 2-50 months could not modulate the high mean serum GPCA titer to a significantly lower level in 37 OLP patients. A 92% GPCA recurrence rate was found in 25 OLP patients receiving no further vitamin B12 treatment during the GPCA-negative remission period.
For GPCA-positive OLP patients, treatment modality containing vitamin B12 can effectively reduce the high serum GPCA level to undetectable level. OLP patients with underlying autoimmune atrophic gastritis trait should receive a maintenance vitamin B12 treatment for life.
本研究旨在测试三种不同治疗方法对胃壁细胞自身抗体（GPCA）阳性口腔扁平苔藓（OLP）患者血清 GPCA 水平降低的疗效。
在 147 例 GPCA 阳性 OLP 患者中，100 例接受了左旋咪唑加维生素 B12 治疗，10 例仅接受了维生素 B12 治疗，37 例仅接受了左旋咪唑治疗。在基线和治疗后测量了 147 例 OLP 患者的血清 GPCA 水平。
左旋咪唑加维生素 B12 治疗 2-50 个月和维生素 B12 治疗 4-44 个月，分别能有效使 100 例和 10 例 OLP 患者的高血清 GPCA 水平降至不可检测水平。然而，左旋咪唑治疗 2-50 个月，不能使 37 例 OLP 患者的高平均血清 GPCA 滴度显著降低。在 GPCA 阴性缓解期未接受进一步维生素 B12 治疗的 25 例 OLP 患者中，发现 GPCA 复发率为 92%。
对于 GPCA 阳性 OLP 患者，含维生素 B12 的治疗方法能有效降低高血清 GPCA 水平至不可检测水平。有潜在自身免疫性萎缩性胃炎特征的 OLP 患者应终身接受维生素 B12 维持治疗。
