采用相转移方法从姜根茎（姜科植物姜Zingiber officinale Roscoe）中鉴定出前所未有的含嘌呤化合物——姜辣素。
Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach.
作者信息
Araya Juan J, Zhang Huaping, Prisinzano Thomas E, Mitscher Lester A, Timmermann Barbara N
机构信息
Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA.
出版信息
Phytochemistry. 2011 Jun;72(9):935-41. doi: 10.1016/j.phytochem.2011.03.007. Epub 2011 Apr 15.
Abstract
Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.
摘要
从姜根茎的甲醇提取物中分离出三种前所未有的含嘌呤化合物，分别命名为[6]-、[8]-和[10]-姜辣素，因为它们分别是[6]-、[8]-和[10]-姜酚的5-(6-氨基-9H-嘌呤-9-基)类似物。该分离方法基于相转移，利用固相试剂，能够快速、选择性地同时分离天然产物提取物中的碱性、酸性和中性成分。
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