Department of Medicine, University of Arizona, Tucson, Arizona 85724, USA.
J Nat Prod. 2009 Mar 27;72(3):403-7. doi: 10.1021/np8006183.
Ginger (Zingiber officinale) supplements are being promoted for arthritis treatment in western societies on the basis of ginger's traditional use as an anti-inflammatory in Chinese and Ayurvedic medicine. However, scientific evidence of ginger's antiarthritic effects is sparse, and its bioactive joint-protective components have not been identified. Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives. Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more efficacious (when normalized to gingerol content) in preventing both joint inflammation and destruction. In conclusion, these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.
姜（Zingiber officinale）补充剂因其在中医和阿育吠陀医学中作为抗炎药的传统用途，正在西方社会中被推广用于关节炎治疗。然而，姜的抗关节炎作用的科学证据很少，其具有生物活性的关节保护成分也尚未确定。因此，对一种特征明确的生姜提取物抑制类风湿关节炎、链球菌细胞壁诱导性关节炎动物模型关节肿胀的能力与仅含姜酚及其衍生物的馏分进行了比较。两种提取物都能有效预防关节炎症。然而，含有精油和更多极性化合物的生姜二氯甲烷提取物在预防关节炎症和破坏方面更有效（归一化为姜酚含量）。总之，这些数据证明了这些姜样品具有非常显著的关节保护作用，并表明非姜酚成分具有生物活性，可以增强更广泛研究的姜酚的抗关节炎作用。
