饮用水对雄性小鼠（Mus musculus）健康影响的代谢组学分析。
A metabonomic analysis on health effects of drinking water on male mice (Mus musculus).
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing, Jiangsu 210046, China.
出版信息
J Hazard Mater. 2011 Jun 15;190(1-3):515-9. doi: 10.1016/j.jhazmat.2011.03.077. Epub 2011 Mar 29.
Health effects of drinking water on the male mice (Mus musculus) were investigated by metabonomics after exposure to the Taihu drinking water for 90 days. Metabonomics data combined with the results of conventional serum biochemistry tests and hepatic histopathology showed that the drinking water induced adverse health effects on the male mice. It was found that the serum levels of pyruvate, glutamine, arginine, lysine, N-acetyl glycoproteins, choline and citrate were significantly decreased in the treatment group. These results indicated that Taihu drinking water may induce damages on mice liver via perturbations of energy metabolism, amino acid metabolism and apoptosis. These observations yielded novel insights regarding the environmental health risk of Taihu drinking water.
采用代谢组学方法研究了饮用太湖水 90 天后雄性小鼠（Mus musculus）的健康影响。代谢组学数据与常规血清生化测试和肝组织病理学结果相结合，表明饮用水对雄性小鼠的健康产生了不良影响。研究发现，实验组血清中丙酮酸、谷氨酰胺、精氨酸、赖氨酸、N-乙酰糖蛋白、胆碱和柠檬酸水平显著降低。这些结果表明，太湖水可能通过干扰能量代谢、氨基酸代谢和细胞凋亡导致小鼠肝脏损伤。这些观察结果为太湖水的环境健康风险提供了新的见解。
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