Chen D S, Sung J L
Acta Hepatogastroenterol (Stuttg). 1978 Dec;25(6):423-30.
Three hundred and eighty-five patients mostly with chronic liver diseases and 729 apparently healthy adults were studied for hepatitis B surface antigen (HBsAg) with reversed passive hemagglutination and antibody (anti-HBs) with passive hemagglutination. In healthy adults around 15% was HBsAg positive and in 45% was anti-HBs positive, estimating hepatitis B virus (HBV) infection in nearly two thirds of the population. The infection already occurred before adulthood. The prevalences of HBsAg were invariably over 80% in chronic hepatitis, cirrhosis and hepatocellular carcinoma (hepatoma) indicating an intimate relationship to HBV. On the contrary, the positive rates of anti-HBs in these diseases were far lower than those in healthy people and patients with other diseases, this is similar to the situation in chronic HBsAg carriers. The prevalence of HBsAg in hepatoma patients was unusually high, being 82.7% in contrast to 11.9% in patients with other malignancies. Not only hepatoma patients with cirrhosis but also those without cirrhosis were found to have high prevalence of HBsAg. The fact indicates an even more intimate relationship between hepatoma and HBV.
对385例主要患有慢性肝病的患者和729名明显健康的成年人进行了研究，采用反向被动血凝法检测乙肝表面抗原（HBsAg），采用被动血凝法检测抗体（抗-HBs）。在健康成年人中，约15%的人HBsAg呈阳性，45%的人抗-HBs呈阳性，估计近三分之二的人群感染了乙肝病毒（HBV）。这种感染在成年前就已发生。慢性肝炎、肝硬化和肝细胞癌（肝癌）患者中HBsAg的患病率始终超过80%，表明与HBV有密切关系。相反，这些疾病中抗-HBs的阳性率远低于健康人和其他疾病患者，这与慢性HBsAg携带者的情况相似。肝癌患者中HBsAg的患病率异常高，为82.7%，而其他恶性肿瘤患者为11.9%。不仅肝硬化的肝癌患者，而且无肝硬化的肝癌患者HBsAg患病率也很高。这一事实表明肝癌与HBV之间的关系更为密切。
