赞比亚卢萨卡地区感染 HIV 的孕妇开始接受抗逆转录病毒治疗的 CD4 资格预测因素。
Predictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia.
机构信息
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
出版信息
J Acquir Immune Defic Syndr. 2011 Aug 15;57(5):e101-5. doi: 10.1097/QAI.0b013e31821d3507.
Abstract
BACKGROUND
In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy.
METHODS
We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women.
RESULTS
The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2).
CONCLUSION
CD4 triage remains a critical element of maternal HIV care and PMTCT.
摘要
背景
在资源有限的情况下，CD4 检测是限制孕妇启动抗逆转录病毒治疗的一个障碍。
方法
我们使用逻辑回归分析方法，确定了 20233 名孕妇的 CD4 细胞计数≤350 个/μL 的预测因素。
结果
表现最佳的模型包括以下任意 3 项：年龄≥28 岁、血红蛋白≤9.8g/dL、妊娠周数≤30 周、体重≤64kg、结核病病史或之前有婴儿在一岁前死亡。该模型的敏感性为 45.7%（95%CI：44.5-47.0），特异性为 70.7%（95%CI：69.6-71.8），错误分类率为 41.4%（95%CI：40.5-42.2）。
结论
CD4 分类仍然是孕产妇 HIV 护理和 PMTCT 的一个关键要素。
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