新的世卫组织抗逆转录病毒治疗预防母婴传播标准的潜在影响。
Potential impact of new WHO criteria for antiretroviral treatment for prevention of mother-to- child HIV transmission.
机构信息
Gertrude H. Sergievsky Center, Department of Epidemiology, Columbia University, New York, New York, USA.
出版信息
AIDS. 2010 Jun 1;24(9):1374-7.
Abstract
We reviewed the potential impact of new WHO criteria for antiretroviral therapy using data from 1025 HIV-infected women and infants followed for 24 months in Lusaka, Zambia. The new criteria require initiating therapy among 68% of pregnant women and, if fully effective, would prevent 92% of maternal deaths and 88% of perinatal and postnatal infections. Using CD4 cell count below 350 cells/microl, irrespective of clinical stage, is more efficient and stricter CD4 cutoffs would be counter productive.
摘要
我们使用来自赞比亚卢萨卡的 1025 名 HIV 感染妇女和婴儿 24 个月的随访数据，评估了新的世卫组织抗逆转录病毒治疗标准的潜在影响。新标准要求对 68%的孕妇开始治疗，如果完全有效，将预防 92%的孕产妇死亡和 88%的围产期和产后感染。使用 CD4 细胞计数低于 350 个/微升，不论临床阶段如何，都更有效，而更严格的 CD4 截止值将适得其反。
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