Kim Sang Hee, Baik Sang-Hyun, Park Chang Soo, Kim Su Jin, Choi Sung Won, Kim Sang Eun
Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea.
Neuroreport. 2011 Jun 11;22(8):407-11. doi: 10.1097/WNR.0b013e328346e16e.
An increasing amount of research has suggested that Internet addiction is associated with abnormalities in the dopaminergic brain system. We hypothesized that Internet addiction would be associated with reduced levels of dopaminergic receptor availability in the striatum compared with controls. To test this hypothesis, a radiolabeled ligand [C]raclopride and positron emission tomography was used to assess dopamine D2 receptor binding potential in men with and without Internet addiction. Consistent with our prediction, individuals with Internet addiction showed reduced levels of dopamine D2 receptor availability in subdivisions of the striatum including the bilateral dorsal caudate and right putamen. This finding contributes to the understanding of neurobiological mechanism of Internet addiction.
越来越多的研究表明，网络成瘾与多巴胺能脑系统异常有关。我们假设，与对照组相比，网络成瘾会导致纹状体中多巴胺能受体可用性水平降低。为了验证这一假设，我们使用放射性标记配体[C]雷氯必利和正电子发射断层扫描来评估有无网络成瘾男性的多巴胺D2受体结合潜力。与我们的预测一致，网络成瘾个体在包括双侧背侧尾状核和右侧壳核在内的纹状体亚区中，多巴胺D2受体可用性水平降低。这一发现有助于理解网络成瘾的神经生物学机制。
