Hou Haifeng, Jia Shaowe, Hu Shu, Fan Rong, Sun Wen, Sun Taotao, Zhang Hong
Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
J Biomed Biotechnol. 2012;2012:854524. doi: 10.1155/2012/854524. Epub 2012 Mar 13.
In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by (99m)Tc-TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the (99m)Tc-TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders.
近年来，网络成瘾障碍（IAD）在全球范围内愈发普遍，人们对其给用户和社会造成的毁灭性影响的认识也迅速提高。然而，IAD的神经生物学机制尚未完全阐明。本研究旨在确定通过（99m）Tc-TRODAT-1单光子发射计算机断层扫描（SPECT）脑部扫描测量的纹状体多巴胺转运体（DAT）水平在IAD患者中是否发生改变。对5名男性IAD受试者和9名年龄匹配的健康对照者进行了SPECT脑部扫描。使用数学模型计算双侧纹状体的体积（V）和重量（W）以及纹状体/全脑的（99m）Tc-TRODAT-1摄取率（Ra）。结果显示，与对照组相比，IAD患者纹状体的DAT表达水平显著降低，V、W和Ra也大幅降低。综上所述，这些结果表明IAD可能对大脑造成严重损害，神经影像学结果进一步说明IAD与多巴胺能脑系统功能障碍有关。我们的研究结果还支持IAD可能与其他成瘾性疾病有相似神经生物学异常的观点。
