Department of Psychiatry, Kaohsiung Armed Forces General Hospital, No. 2 Chung Cheng 1st Road, Kaohsiung, Taiwan.
Psychiatr Q. 2011 Dec;82(4):343-51. doi: 10.1007/s11126-011-9177-z.
This study aimed to explore the relationship between dosage of paliperidone and drug attitude, and also clarify the factors associated with drug attitude, using Intention-to-Treat (ITT) analysis. Three hundred thirty-one patients diagnosed with schizophrenia, who prescribed paliperidone between April 2008 and April 2009, from 10 hospitals in Taiwan were enrolled. By structural equation modeling, inpatient/outpatient status associated with occupation status, sex, and score on the Clinical Global Impression-Severity (CGIS) Scale. The score on the Personal and Social Performance (PSP) Scale associated with occupation status, inpatient/outpatient status, and the score on the CGIS Scale. The scores on the DAI-10 associated with the score on the PSP Scale and age. Good drug attitude and medication adherence significantly related to good social interaction. We should enhance the drug attitude and medication adherence of patients with schizophrenia who have poor social interaction to improve the outcome of schizophrenia.
本研究旨在通过意向性治疗（ITT）分析，探讨帕利哌酮剂量与药物态度之间的关系，并阐明与药物态度相关的因素。本研究共纳入了 331 名于 2008 年 4 月至 2009 年 4 月期间在台湾的 10 家医院被诊断为精神分裂症并接受帕利哌酮治疗的患者。通过结构方程建模，住院/门诊状态与职业状态、性别和临床总体印象严重程度量表（CGIS）评分相关。个人和社会表现量表（PSP）评分与职业状态、住院/门诊状态和 CGIS 评分相关。DAI-10 评分与 PSP 评分和年龄相关。良好的药物态度和药物依从性与良好的社会互动显著相关。我们应该增强药物态度和药物依从性，以改善社会互动不良的精神分裂症患者的结局。
