Dahan M, Paillole C, Ferreira B, Gourgon R
Bichat University Hospital, Division of Cardiology, Paris, France.
Eur Heart J. 1990 Nov;11 Suppl G:39-45. doi: 10.1093/eurheartj/11.suppl_g.39.
The aims of the study were (1) to describe the consequences of aging and hypertension on left ventricular geometry and physical properties of the aorta, (2) to study interactions between some physical properties of the aorta and left ventricular geometry in normal (NT) and hypertensive patients (HT) using Doppler echocardiography. Forty-five healthy normotensive subjects (age range 21 to 84 years) and 20 untreated sustained hypertensive patients (age range 20 to 70 years) were studied. We measured (1) resting arterial blood pressure with a Dinamap, (2) left ventricular radius (r), thickness (th), mass (LVM), th/r ratio and aortic diameter (AD) by M-mode echocardiography with 2D control, and (3) pulse wave velocity (PWV) in the descending thoracic aorta from aortic velocity tracings recorded by pulsed wave Doppler in the isthmus and near the diaphragm. The PWV/AD ratio was derived. In hypertensive patients, blood pressure, PWV, AD, PWV/AD, th, th/r and LVM were significantly increased compared with normal subjects at a similar age. In normal subjects, PWV, AD, PWV/AD, th, r, th/r and LVM correlated significantly to age. In both groups, th/r ratio was significantly related to PWV and PWV/AD. The Doppler echocardiographic method of PWV measurement is feasible, reproducible and gives similar results to other methods, especially the invasive haemodynamic method. Doppler echocardiography is an adequate method to study left ventricular geometry and some physical properties of the aorta. It can be used to assess the consequences of aging and hypertension on both left ventricle (concentric hypertrophy) and aorta (increase of aortic stiffness).
（1）描述衰老和高血压对左心室几何形状及主动脉物理特性的影响；（2）使用多普勒超声心动图研究正常（NT）和高血压患者（HT）中主动脉的某些物理特性与左心室几何形状之间的相互作用。对45名健康的血压正常受试者（年龄范围21至84岁）和20名未经治疗的持续性高血压患者（年龄范围20至70岁）进行了研究。我们测量了：（1）使用动态血压监测仪测量静息动脉血压；（2）通过二维控制的M型超声心动图测量左心室半径（r）、厚度（th）、质量（LVM）、th/r比值和主动脉直径（AD）；（3）通过脉冲波多普勒在主动脉峡部和靠近膈肌处记录的主动脉速度描记图测量胸降主动脉的脉搏波速度（PWV）。计算得出PWV/AD比值。与年龄相仿的正常受试者相比，高血压患者的血压、PWV、AD、PWV/AD、th、th/r和LVM显著升高。在正常受试者中，PWV、AD、PWV/AD、th、r、th/r和LVM与年龄显著相关。在两组中，th/r比值均与PWV和PWV/AD显著相关。多普勒超声心动图测量PWV的方法可行、可重复，且与其他方法（尤其是有创血流动力学方法）结果相似。多普勒超声心动图是研究左心室几何形状和主动脉某些物理特性的合适方法。它可用于评估衰老和高血压对左心室（向心性肥厚）和主动脉（主动脉僵硬度增加）的影响。
