Department of Ophthalmology, Medical Faculty, Celal Bayar University, Manisa, Turkey.
Curr Eye Res. 2011 May;36(5):399-403. doi: 10.3109/02713683.2011.553307.
To determine if corneal biomechanical properties change during phases of the menstrual cycle.
Twenty-five healthy women of reproductive age with no ocular pathology or systemic diseases were recruited. Corneal hysteresis, corneal resistance factor, Goldman-correlated intraocular pressure, and corneal-compensated intraocular pressure were measured by a Reichert ocular response analyzer at three phases of the menstrual cycle, beginning on days 3 to 5 (follicular phase), again at ovulation (days 14-16, ovulatory phase), and at the end of the cycle (days 25-28, luteal phase).
Twenty-one participants completed the study. The mean corneal hysteresis values at follicular, ovulatory, and luteal phases were 10.7, 10.7, and 10.7 mmHg (p > 0.05), and the mean corneal resistance factor values at the same time points were 9.9, 9.9, and 9.8 mmHg (p > 0.05), respectively. Corneal-compensated intraocular pressure and Goldman-correlated intraocular pressure readings were stable during the course (p > 0.05 for all).
Corneal biomechanical properties and intraocular pressure as measured by an ocular response analyzer do not change statistically significantly during the different phases of the menstrual cycle. We conclude that measurements of the ocular response analyzer can be safely utilized in healthy female subjects without considering the possible effects of varying hormonal levels during the menstrual cycle.
确定角膜生物力学特性在月经周期各阶段是否发生变化。
招募了 25 名年龄在生育期、无眼部疾病或全身疾病的健康女性。在月经周期的三个阶段（第 3 至 5 天的卵泡期、第 14-16 天的排卵期和第 25-28 天的黄体期），使用 Reichert 眼反应分析仪测量角膜滞后、角膜阻力因子、Goldman 相关眼压和角膜补偿眼压。
21 名参与者完成了研究。卵泡期、排卵期和黄体期的平均角膜滞后值分别为 10.7、10.7 和 10.7mmHg（p>0.05），相应的平均角膜阻力因子值分别为 9.9、9.9 和 9.8mmHg（p>0.05）。角膜补偿眼压和 Goldman 相关眼压读数在整个过程中均保持稳定（p>0.05）。
使用眼反应分析仪测量的角膜生物力学特性和眼压在月经周期的不同阶段没有统计学上的显著变化。我们得出结论，在健康女性中，测量眼反应分析仪时可以安全地使用，而无需考虑月经周期中激素水平变化的可能影响。
