Department of Ophthalmology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Cornea. 2010 Jun;29(6):628-31. doi: 10.1097/ICO.0b013e3181c3306a.
The Reichert ocular response analyzer (ORA) measures corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when its structure is submitted to a force induced by an air jet. This study was designed to examine corneal biomechanical properties and intraocular pressure in patients with systemic sclerosis (SSc) and to compare with control eyes.
ORA measurements were performed on the right eyes of 29 patients with SSc (group 1) and 29 healthy people who served as the control group (group 2). Corneal hysteresis, corneal resistance factor (CRF), and intraocular pressure [Goldmann correlated (IOPg) and corneal compensated] were recorded with ORA.
Mean age of patients with SSc and control groups were 51.7 +/- 11.1 and 50.3 +/- 10.8 years, respectively. Mean (+/-SD) of the corneal hysteresis and CRF readings were 9.8 +/- 1.7 versus 9.5 +/- 1.2 mm Hg (P > 0.05) and 10.0 +/- 1.5 versus 9.2 +/- 1.4 mm Hg (P < 0.05), in groups 1 and 2, respectively. Mean (+/-SD) of the IOPg and intraocular pressure corneal-compensated recordings were 15.9 +/- 2.5 versus 14.1 +/- 2.4 mm Hg (P < 0.05) and 16.9 +/- 3.2 versus 15.6 +/- 2.9 mm Hg (P > 0.05), in groups 1 and 2, respectively. Statistical analysis revealed significant differences for CRF and IOPg between the study groups.
The mean CRF and IOPg values of patients with SSc were higher when compared with normal controls. According to the results of our study, one can conclude that corneal biomechanical properties would be changed in patients with SSc and this can be determined by CRF.
Reichert 眼反应分析仪(ORA)通过监测和分析角膜在空气喷射力作用下的结构变化,测量活体角膜生物力学特性。本研究旨在检测系统性硬化症(SSc)患者的角膜生物力学特性和眼内压,并与对照组进行比较。
对 29 例 SSc 患者(组 1)和 29 名健康人(对照组 2)的右眼进行 ORA 测量。用 ORA 记录角膜滞后、角膜阻力因子(CRF)和眼内压[Goldmann 相关眼压(IOPg)和角膜补偿]。
SSc 组和对照组患者的平均年龄分别为 51.7±11.1 岁和 50.3±10.8 岁。组 1 和组 2 的角膜滞后和 CRF 读数的平均值(±SD)分别为 9.8±1.7mmHg 与 9.5±1.2mmHg(P>0.05)和 10.0±1.5mmHg 与 9.2±1.4mmHg(P<0.05)。组 1 和组 2 的 IOPg 和眼压角膜补偿读数的平均值(±SD)分别为 15.9±2.5mmHg 与 14.1±2.4mmHg(P<0.05)和 16.9±3.2mmHg 与 15.6±2.9mmHg(P>0.05)。统计学分析显示,两组间 CRF 和 IOPg 差异有统计学意义。
与正常对照组相比,SSc 患者的平均 CRF 和 IOPg 值较高。根据我们的研究结果,可以得出结论,SSc 患者的角膜生物力学特性会发生变化,这可以通过 CRF 来确定。