Laboratoire de Physiologie Cellulaire et Végétale, UMR 5168, CNRS, CEA, INRA, Université Joseph Fourier Grenoble I, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, France.
Biochimie. 2012 Jan;94(1):86-93. doi: 10.1016/j.biochi.2011.03.012. Epub 2011 Apr 12.
Phosphatidic acid (PA) is a precursor metabolite for phosphoglycerolipids and also for galactoglycerolipids, which are essential lipids for formation of plant membranes. PA has in addition a main regulatory role in a number of developmental processes notably in the response of the plant to environmental stresses. We review here the different pools of PA dispatched at different locations in the plant cell and how these pools are modified in different growth conditions, particularly during plastid membrane biogenesis and when the plant is exposed to phosphate deprivation. We analyze how these modifications can affect galactolipid synthesis by tuning the activity of MGD1 enzyme allowing a coupling of phospho- and galactolipid metabolisms. Some mechanisms are considered to explain how physicochemical properties of PA allow this lipid to act as a central internal sensor in plant physiology.
磷脂酸（PA）是磷甘油酯和半乳糖甘油酯的前体代谢物，对于植物膜的形成至关重要。PA 在许多发育过程中具有主要的调节作用，特别是在植物对环境胁迫的反应中。在这里，我们回顾了在植物细胞的不同位置分配的不同 PA 池，以及在不同的生长条件下，特别是在质体膜生物发生期间和植物受到磷酸盐剥夺时，这些池如何被修饰。我们分析了这些修饰如何通过调节 MGD1 酶的活性来影响半乳糖脂的合成，从而使磷酸和半乳糖脂代谢偶联。一些机制被认为可以解释 PA 的物理化学性质如何使其能够作为植物生理学中的中央内部传感器发挥作用。
