核环境中的染色质。
Chromatin in the nuclear landscape.
作者信息
Beck D B, Bonasio R, Kaneko S, Li G, Li G, Margueron R, Oda H, Sarma K, Sims R J, Son J, Trojer P, Reinberg D
机构信息
Howard Hughes Medical Institute and Department of Biochemistry, School of Medicine, New York University, New York, New York 10016, USA.
出版信息
Cold Spring Harb Symp Quant Biol. 2010;75:11-22. doi: 10.1101/sqb.2010.75.052. Epub 2011 Apr 18.
Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the basic mechanisms regulating the formation and maintenance of chromatin, specifically concerning Polycomb repressive complex 2 (PRC2) and PR-Set7. PRC2 is responsible for catalyzing trimethylation of lysine 27 of histone H3 and thus has a critical role in the formation of facultative heterochromatin. PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response. We have also expanded our work to establish novel techniques and approaches to determine how chromatin is spatially regulated within the nuclear landscape.
染色质影响着核组织和功能的诸多方面，即便不是所有方面。出于这个原因，我们将注意力集中在阐明一些调节染色质形成和维持的基本机制上，特别是关于多梳抑制复合物2（PRC2）和PR-Set7。PRC2负责催化组蛋白H3赖氨酸27的三甲基化，因此在兼性异染色质的形成中起关键作用。PR-Set7负责催化组蛋白H4赖氨酸20的单甲基化，是细胞周期正常进展和DNA损伤反应所必需的。我们还扩展了工作，以建立新技术和方法来确定染色质在核格局中是如何进行空间调控的。
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