Suppr超能文献

核环境中的染色质。

Chromatin in the nuclear landscape.

作者信息

Beck D B, Bonasio R, Kaneko S, Li G, Li G, Margueron R, Oda H, Sarma K, Sims R J, Son J, Trojer P, Reinberg D

机构信息

Howard Hughes Medical Institute and Department of Biochemistry, School of Medicine, New York University, New York, New York 10016, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 2010;75:11-22. doi: 10.1101/sqb.2010.75.052. Epub 2011 Apr 18.

Abstract

Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the basic mechanisms regulating the formation and maintenance of chromatin, specifically concerning Polycomb repressive complex 2 (PRC2) and PR-Set7. PRC2 is responsible for catalyzing trimethylation of lysine 27 of histone H3 and thus has a critical role in the formation of facultative heterochromatin. PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response. We have also expanded our work to establish novel techniques and approaches to determine how chromatin is spatially regulated within the nuclear landscape.

摘要

染色质影响着核组织和功能的诸多方面,即便不是所有方面。出于这个原因,我们将注意力集中在阐明一些调节染色质形成和维持的基本机制上,特别是关于多梳抑制复合物2(PRC2)和PR-Set7。PRC2负责催化组蛋白H3赖氨酸27的三甲基化,因此在兼性异染色质的形成中起关键作用。PR-Set7负责催化组蛋白H4赖氨酸20的单甲基化,是细胞周期正常进展和DNA损伤反应所必需的。我们还扩展了工作,以建立新技术和方法来确定染色质在核格局中是如何进行空间调控的。

相似文献

1
Chromatin in the nuclear landscape.
Cold Spring Harb Symp Quant Biol. 2010;75:11-22. doi: 10.1101/sqb.2010.75.052. Epub 2011 Apr 18.
2
Histone methylation by PRC2 is inhibited by active chromatin marks.
Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.
3
IMITATION SWITCH is required for normal chromatin structure and gene repression in PRC2 target domains.
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). doi: 10.1073/pnas.2010003118.
5
Inner workings and regulatory inputs that control Polycomb repressive complex 2.
Chromosoma. 2012 Jun;121(3):221-34. doi: 10.1007/s00412-012-0361-1. Epub 2012 Feb 19.
6
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
Genes Dev. 2004 Jun 1;18(11):1251-62. doi: 10.1101/gad.300704. Epub 2004 May 14.
7
The Polycomb complex PRC2 and its mark in life.
Nature. 2011 Jan 20;469(7330):343-9. doi: 10.1038/nature09784.
8
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.
PLoS Biol. 2018 Aug 6;16(8):e2004986. doi: 10.1371/journal.pbio.2004986. eCollection 2018 Aug.

引用本文的文献

1
Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.
Nature. 2023 Apr;616(7955):176-182. doi: 10.1038/s41586-023-05841-y. Epub 2023 Mar 29.
3
pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiation.
Genes Dis. 2014 Sep 30;1(2):174-187. doi: 10.1016/j.gendis.2014.09.007. eCollection 2014 Dec.
4
Evidence for the association of chromatin and microRNA regulation in the human genome.
Oncotarget. 2017 Aug 12;8(41):70958-70966. doi: 10.18632/oncotarget.20214. eCollection 2017 Sep 19.
6
EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21.
Open Biol. 2016 Apr;6(4):150227. doi: 10.1098/rsob.150227. Epub 2016 Apr 20.
9
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.
Science. 2014 Aug 29;345(6200):1065-70. doi: 10.1126/science.1255104.
10
Chromatin-bound RNA and the neurobiology of psychiatric disease.
Neuroscience. 2014 Apr 4;264:131-41. doi: 10.1016/j.neuroscience.2013.06.051. Epub 2013 Jul 3.

本文引用的文献

1
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
Mol Cell. 2010 Nov 12;40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.
2
Descriptive no more: the dawn of high-throughput microscopy.
Trends Cell Biol. 2010 Sep;20(9):503-6. doi: 10.1016/j.tcb.2010.06.008. Epub 2010 Jul 29.
4
Jarid2 and PRC2, partners in regulating gene expression.
Genes Dev. 2010 Feb 15;24(4):368-80. doi: 10.1101/gad.1886410. Epub 2010 Feb 1.
5
A region of the human HOXD cluster that confers polycomb-group responsiveness.
Cell. 2010 Jan 8;140(1):99-110. doi: 10.1016/j.cell.2009.12.022.
6
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.
Nature. 2010 Feb 11;463(7282):818-22. doi: 10.1038/nature08760. Epub 2010 Jan 17.
7
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
Cell. 2009 Dec 24;139(7):1303-14. doi: 10.1016/j.cell.2009.12.003.
9
Histones: annotating chromatin.
Annu Rev Genet. 2009;43:559-99. doi: 10.1146/annurev.genet.032608.103928.
10
Structural studies of a four-MBT repeat protein MBTD1.
PLoS One. 2009 Oct 20;4(10):e7274. doi: 10.1371/journal.pone.0007274.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验