From INSERM UMR-S 970, Paris Cardiovascular Research Center (PARCC), Université Paris Descartes, Sorbonne Paris Cité, Paris, France (H.A.-O., Z.M., A.T.); Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Paris, France (H.A.-O.); and Department of Medicine, University of Cambridge, Cambridge, United Kingdom (A.P.S., Z.M.).
Circ Res. 2014 May 9;114(10):1640-60. doi: 10.1161/CIRCRESAHA.114.302761.
Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in the development of atherosclerosis. Both innate and adaptive immunity are involved in this process. Adaptive immune responses develop against an array of potential antigens presented to effector T lymphocytes by antigen-presenting cells, especially dendritic cells. Functional analysis of the role of different T-cell subsets identified the Th1 responses as proatherogenic, whereas regulatory T-cell responses exert antiatherogenic activities. The effect of Th2 and Th17 responses is still debated. Atherosclerosis is also associated with B-cell activation. Recent evidence established that conventional B-2 cells promote atherosclerosis. In contrast, innate B-1 B cells offer protection through secretion of natural IgM antibodies. This review discusses the recent development in our understanding of the role of T- and B-cell subsets in atherosclerosis and addresses the role of dendritic cell subpopulations in the control of adaptive immunity.
慢性炎症反应导致脂蛋白在动脉壁中堆积，这是动脉粥样硬化形成的核心。固有免疫和适应性免疫都参与了这一过程。适应性免疫反应针对抗原呈递细胞（尤其是树突状细胞）向效应 T 淋巴细胞呈递的一系列潜在抗原而产生。对不同 T 细胞亚群功能的分析确定了 Th1 反应具有促动脉粥样硬化作用，而调节性 T 细胞反应则具有抗动脉粥样硬化作用。Th2 和 Th17 反应的作用仍存在争议。动脉粥样硬化也与 B 细胞激活有关。最近的证据表明，常规 B-2 细胞可促进动脉粥样硬化。相比之下，先天 B-1 B 细胞通过分泌天然 IgM 抗体提供保护。本文讨论了我们对 T 细胞和 B 细胞亚群在动脉粥样硬化中的作用的最新认识，并探讨了树突状细胞亚群在调节适应性免疫中的作用。
