铁氧化物介导的环状脂肪族醚α-位的直接 C-H 芳基化/烷基化。

Iron oxide mediated direct C-H arylation/alkylation at α-position of cyclic aliphatic ethers.

机构信息

Medicinal Chemistry Division, Indian Institute of Integrative Medicine (Council of Scientific & Industrial Research), Jammu 180 001, India.

出版信息

Chem Commun (Camb). 2011 May 28;47(20):5852-4. doi: 10.1039/c1cc11094b. Epub 2011 Apr 18.

DOI:10.1039/c1cc11094b

PMID:21503345

Abstract

We report a new and efficient iron oxide catalyzed cross-coupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and α-hydrogen bearing cyclic aliphatic ethers via activation of C(sp(3))-H. This is the first example of iron oxide mediated direct C-C bond formation without expensive or toxic ligands.

摘要

我们报道了一种新的、有效的氧化铁催化的交叉偶联反应，该反应通过 C(sp(3))-H 的活化，将有机金属物种（如烷基/芳基卤化镁或有机锂物种）与含α-氢的环状脂肪族醚进行偶联。这是第一个没有使用昂贵或有毒配体的氧化铁介导的直接 C-C 键形成的例子。