Escola Paulista de Medicina, Unifesp.
Arq Bras Cardiol. 2011 May;96(5):420-4. doi: 10.1590/s0066-782x2011005000049. Epub 2011 Apr 15.
Congestive heart failure (CHF) caused by myocardial infarction in rats is the most commonly used experimental model to study the congestive heart failure syndrome. Following myocardial necrosis, the manifestations observed in rats very satisfactorily reproduce the findings in humans with cardiac decompensation and substantiate the study of CHF pathogenesis, pathophysiology, and treatment. Two features are inadequate in the model: the high mortality rate in the first 24 hours after coronary occlusion, and the considerable diversity of myocardial infarct sizes. In this review we described methodological and pathophysiological aspects of the model, concluding with a reference to an alternative technique, which uses radio frequency electric current to produce myocardial necrosis, and evolves with low mortality rates and homogeneous infarct sizes.
心肌梗死后导致的充血性心力衰竭（CHF）是最常用于研究充血性心力衰竭综合征的实验模型。在心肌坏死之后，在大鼠中观察到的表现非常满意地再现了人类心脏代偿失调的发现，并证实了 CHF 发病机制、病理生理学和治疗的研究。该模型有两个不足之处：在冠状动脉闭塞后 24 小时内的高死亡率，以及心肌梗死大小的相当大的多样性。在这篇综述中，我们描述了该模型的方法学和病理生理学方面，最后提到了一种替代技术，该技术使用射频电流产生心肌坏死，并且具有低死亡率和均匀的梗死大小。
