Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Curr Cardiol Rev. 2020;16(4):292-305. doi: 10.2174/1573403X15666190729153026.
In general, postmenopausal women present higher mortality, and worse prognosis after myocardial infarction (MI) compared to men, due to estrogen deficiency. After MI, cardiovascular alterations occur such as the autonomic imbalance and the pro-inflammatory cytokines increase. In this sense, therapies that aim to minimize deleterious effects caused by myocardial ischemia are important. Aerobic training has been proposed as a promising intervention in the prevention of cardiovascular diseases. On the other hand, some studies have attempted to identify potential biomarkers for cardiovascular diseases or specifically for MI. For this purpose, metabolomics has been used as a tool in the discovery of cardiovascular biomarkers. Therefore, the objective of this work is to discuss the changes involved in ovariectomy, myocardial infarction, and aerobic training, with emphasis on inflammation and metabolism.
一般来说，绝经后女性由于雌激素缺乏，其心肌梗死（MI）后的死亡率和预后较男性更差。MI 后，心血管会发生改变，如自主神经失衡和促炎细胞因子增加。在这种情况下，旨在最小化心肌缺血引起的有害影响的治疗方法非常重要。有氧运动已被提议作为预防心血管疾病的一种有前途的干预措施。另一方面，一些研究试图确定心血管疾病或特定于 MI 的潜在生物标志物。为此，代谢组学已被用作发现心血管生物标志物的工具。因此，本工作的目的是讨论卵巢切除术、心肌梗死和有氧运动所涉及的变化，重点关注炎症和代谢。
