Zhang S R
Institute of Materia Medica, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Jun;12(3):198-202.
3-hydroxy-lup-20(29) en-23-28-dioic acid (HLEDA) at doses of 50-100 mg/kg was found to be an effective anti-ulcer agent in three rat experimental gastric ulcer models: the indomethacin-induced, pyloric ligation-induced, and absolute alcohol-induced ulcers. Its anti-ulcer activities were similar to those of carbenoxolone. HLEDA was shown to increase the hexosamine levels in gastric juice collected from pylorus ligated stomachs. No influence on gastric secretion and peptic activity was observed. Carbenoxolone was found to significantly inhibit the elimination of Na+ and K+ in rat urine. HLEDA had no effect on the elimination of Na+ and K+.
在三种大鼠实验性胃溃疡模型（吲哚美辛诱导型、幽门结扎诱导型和无水乙醇诱导型溃疡）中，发现剂量为50-100mg/kg的3-羟基羽扇豆-20(29)-烯-23,28-二酸（HLEDA）是一种有效的抗溃疡剂。其抗溃疡活性与甘草次酸相似。HLEDA可使从幽门结扎胃中收集的胃液中的氨基己糖水平升高。未观察到对胃分泌和消化活性有影响。发现甘草次酸可显著抑制大鼠尿液中Na+和K+的排泄。HLEDA对Na+和K+的排泄没有影响。
