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彩色序列联觉的遗传学:与 16q 连锁的暗示证据和该病症的遗传异质性。

The genetics of colored sequence synesthesia: suggestive evidence of linkage to 16q and genetic heterogeneity for the condition.

机构信息

Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.

出版信息

Behav Brain Res. 2011 Sep 30;223(1):48-52. doi: 10.1016/j.bbr.2011.03.071. Epub 2011 Apr 8.

DOI:10.1016/j.bbr.2011.03.071
PMID:21504763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4075137/
Abstract

Synesthesia is a perceptual condition in which sensory stimulation triggers anomalous sensory experiences. In colored sequence synesthesia (CSS), color experiences are triggered by sequences such as letters or numbers. We performed a family based linkage analysis to identify genetic loci responsible for the increased neural crosstalk underlying CSS. Our results implicate a 23 MB region at 16q12.2-23.1, providing the first step in understanding the molecular basis of CSS.

摘要

联觉是一种感知状态,其中感官刺激会引发异常的感官体验。在彩色序列联觉(CSS)中,颜色体验会被字母或数字等序列触发。我们进行了一项基于家族的连锁分析,以确定导致 CSS 背后的神经串扰增加的遗传基因座。我们的结果表明,在 16q12.2-23.1 处存在一个 23MB 的区域,这为理解 CSS 的分子基础迈出了第一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/8b438ab2fab2/nihms-599649-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/8adbcf1ae102/nihms-599649-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/5b9e76e5ecab/nihms-599649-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/addffdd5096b/nihms-599649-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/8b438ab2fab2/nihms-599649-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/8adbcf1ae102/nihms-599649-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/5b9e76e5ecab/nihms-599649-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/addffdd5096b/nihms-599649-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2be/4075137/8b438ab2fab2/nihms-599649-f0004.jpg

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