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精神分裂症的功能连接和脑网络。

Functional connectivity and brain networks in schizophrenia.

机构信息

Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.

出版信息

J Neurosci. 2010 Jul 14;30(28):9477-87. doi: 10.1523/JNEUROSCI.0333-10.2010.

Abstract

Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with schizophrenia (10 male, 2 female). We investigated between-group differences in strength and diversity of functional connectivity in the 0.06-0.125 Hz frequency interval, and some topological properties of undirected graphs constructed from thresholded interregional correlation matrices. In people with schizophrenia, strength of functional connectivity was significantly decreased, whereas diversity of functional connections was increased. Topologically, functional brain networks had reduced clustering and small-worldness, reduced probability of high-degree hubs, and increased robustness in the schizophrenic group. Reduced degree and clustering were locally significant in medial parietal, premotor and cingulate, and right orbitofrontal cortical nodes of functional networks in schizophrenia. Functional connectivity and topological metrics were correlated with each other and with behavioral performance on a verbal fluency task. We conclude that people with schizophrenia tend to have a less strongly integrated, more diverse profile of brain functional connectivity, associated with a less hub-dominated configuration of complex brain functional networks. Alongside these behaviorally disadvantageous differences, however, brain networks in the schizophrenic group also showed a greater robustness to random attack, pointing to a possible benefit of the schizophrenia connectome, if less extremely expressed.

摘要

精神分裂症通常被认为是大脑大网络中各组成部分之间连接的紊乱。我们通过测量来自 15 位健康志愿者(14 位男性,1 位女性)和 12 位被诊断为精神分裂症患者(10 位男性,2 位女性)的静息态 fMRI 时间序列的功能连接和功能网络拓扑结构的各个方面来验证这个假设。我们在 0.06-0.125Hz 的频率间隔内研究了组间功能连接强度和多样性的差异,以及从无向相关矩阵构建的阈值网络拓扑属性的差异。在精神分裂症患者中,功能连接的强度显著降低,而功能连接的多样性增加。从拓扑角度来看,功能脑网络的聚类和小世界特性降低,高连接度中枢的概率降低,而在精神分裂症患者中,鲁棒性增加。在精神分裂症患者的功能网络的内侧顶叶、运动前和扣带皮质以及右侧眶额皮质节点中,度和聚类的降低具有局部显著性。功能连接和拓扑指标彼此相关,与言语流畅性任务的行为表现相关。我们得出的结论是,精神分裂症患者的大脑功能连接具有较弱的整合和更多样化的特征,与复杂大脑功能网络中较少的中枢主导配置相关。然而,与这些行为上不利的差异相伴的是,精神分裂症患者的大脑网络对随机攻击的鲁棒性也有所增加,这表明精神分裂症连接组可能具有一定的优势,尽管其表达程度较低。

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本文引用的文献

1
Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia.
Hum Brain Mapp. 2010 Dec;31(12):2003-14. doi: 10.1002/hbm.20993. Epub 2010 Mar 11.
2
What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders?
Curr Opin Psychiatry. 2010 May;23(3):239-49. doi: 10.1097/YCO.0b013e328337d78d.
3
Time-frequency dynamics of resting-state brain connectivity measured with fMRI.
Neuroimage. 2010 Mar;50(1):81-98. doi: 10.1016/j.neuroimage.2009.12.011. Epub 2009 Dec 16.
4
Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia.
Arch Gen Psychiatry. 2009 Aug;66(8):811-22. doi: 10.1001/archgenpsychiatry.2009.91.
5
Cognitive fitness of cost-efficient brain functional networks.
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11747-52. doi: 10.1073/pnas.0903641106. Epub 2009 Jun 29.
6
Efficiency of functional brain networks and intellectual performance.
J Neurosci. 2009 Jun 10;29(23):7619-24. doi: 10.1523/JNEUROSCI.1443-09.2009.
7
Human brain networks in health and disease.
Curr Opin Neurol. 2009 Aug;22(4):340-7. doi: 10.1097/WCO.0b013e32832d93dd.
8
Brain anatomical network and intelligence.
PLoS Comput Biol. 2009 May;5(5):e1000395. doi: 10.1371/journal.pcbi.1000395. Epub 2009 May 29.
9
Complex brain networks: graph theoretical analysis of structural and functional systems.
Nat Rev Neurosci. 2009 Mar;10(3):186-98. doi: 10.1038/nrn2575. Epub 2009 Feb 4.
10
Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia.
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1279-84. doi: 10.1073/pnas.0809141106. Epub 2009 Jan 21.

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