Ohto Hitoshi, Nollet Kenneth E
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Transfus Apher Sci. 2011 Jun;44(3):321-5. doi: 10.1016/j.transci.2011.03.008. Epub 2011 Apr 19.
Platelet storage lesion (PSL), correlating with reduced in vivo recovery/survival and hemostatic capacity after transfusion, is characterized essentially by morphological and molecular evidence of platelet activation and energy consumption in the medium. Processes that limit shelf-life are multifactorial, and include both necrosis and apoptosis. PSL is greatly influenced by factors including duration of storage, temperature, ratio of platelet number to media volume, solution composition with respect to energy content and buffering capacity, and gas permeability of the container. Recent progress for slowing PSL has been made with storage media that more effectively fuel ATP production and buffer the inevitable effects of metabolism. Improved oxygen-permeability of containers also helps to maintain aerobic-dominant glycolysis. Patients stand to benefit from platelet products of higher intrinsic quality that store well until the moment of transfusion.
血小板储存损伤（PSL）与输血后体内回收率/存活率降低及止血能力相关，其主要特征是血小板活化的形态学和分子学证据以及培养基中的能量消耗。限制保质期的过程是多因素的，包括坏死和凋亡。PSL受到多种因素的极大影响，包括储存时间、温度、血小板数量与培养基体积的比例、与能量含量和缓冲能力相关的溶液组成以及容器的气体渗透性。最近，通过更有效地促进ATP生成和缓冲代谢不可避免影响的储存培养基，在减缓PSL方面取得了进展。容器改善的氧气渗透性也有助于维持以有氧为主的糖酵解。患者有望受益于内在质量更高的血小板产品，这些产品在输血前能良好储存。
