Devine Dana V, Serrano Katherine
Research and Development, Canadian Blood Services, 2350 Health Sciences Mall, Vancouver, Canada.
Clin Lab Med. 2010 Jun;30(2):475-87. doi: 10.1016/j.cll.2010.02.002.
The gradual loss of quality in stored platelets as measured collectively with various metabolic, functional, and morphologic in vitro assays is known as the platelet storage lesion. With the advent of pathogen reduction technologies and improved testing that can greatly reduce the risk for bacterial contamination, the platelet storage lesion is emerging as the main challenge to increasing the shelf life of platelet concentrates. This article discusses the contribution of platelet production methods to the storage lesion, long-established and newly developed methods used to determine platelet quality, and the significance for clinical transfusion outcome. Highlighted are the novel technologies applied to platelet storage including platelet additive solutions and pathogen inactivation.
通过各种代谢、功能和形态学体外检测共同测定，储存血小板质量的逐渐丧失被称为血小板储存损伤。随着病原体灭活技术的出现以及能大幅降低细菌污染风险的改进检测方法的出现，血小板储存损伤正成为延长血小板浓缩物保质期的主要挑战。本文讨论了血小板生产方法对储存损伤的影响、用于确定血小板质量的长期存在和新开发的方法，以及对临床输血结果的意义。重点介绍了应用于血小板储存的新技术，包括血小板添加剂溶液和病原体灭活。
