Ritsner M S, Karas' S I, Chernykh E I
Genetika. 1990 Dec;26(12):2232-9.
The contribution of genetic, constitutional and environmental factors to the clinical polymorphism of schizophrenia was analysed. A sample from 353 pedigrees of the patients suffering from the manifest forms of schizophrenia which inhabited five districts of Tomsk region was studied using multifactorial threshold and single locus diallele models. It is established that the severity of the psychosis is mainly determined by autosomal genetic factors, the proportion of the affective disorders being specified by gonosomal factors. The type of the course of schizophrenia is closely connected with the patients' somatotype. Common environmental influences and peculiarities of personality before onset are linked with no characteristics of the clinical polymorphism studied.
分析了遗传、体质和环境因素对精神分裂症临床多态性的影响。采用多因素阈值模型和单基因座双等位基因模型，对来自托木斯克地区五个区的353个患有明显精神分裂症的家系样本进行了研究。结果表明，精神病的严重程度主要由常染色体遗传因素决定，情感障碍的比例由性染色体因素决定。精神分裂症的病程类型与患者的体型密切相关。常见的环境影响和发病前的人格特质与所研究的临床多态性特征无关。
