Institute of Zoonoses, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
Molecules. 2011 Apr 19;16(4):3371-9. doi: 10.3390/molecules16043371.
Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca2+ ([Ca2+]i) elevation, scavenge reactive oxygen species (ROS) and increase 3'-5'-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn't influence 3'-5'-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca2+]i, ROS occur via a cAMP-dependent pathway.
红景天苷是红景天的主要成分之一，具有多种药理作用，包括抗氧化作用，但它的抗氧化作用的信号转导途径尚不清楚。在本研究中，我们发现红景天苷能减轻过氧化氢（H2O2）诱导的 HL-7702 细胞损伤，抑制 H2O2 诱导的胞浆游离 Ca2+([Ca2+]i)升高，以剂量依赖方式清除活性氧（ROS）并增加 3'-5'-环磷酸腺苷（cAMP）水平，但不影响 3'-5'-环磷酸鸟苷（cGMP）水平。因此，这些结果表明红景天苷的抗氧化作用与[Ca2+]i 的下调有关，ROS 通过 cAMP 依赖途径发生。
