Mozzanica N, Pigatto P D
2nd Department of Dermatology, University of Milan, Italy.
Contact Dermatitis. 1990 Nov;23(5):336-40. doi: 10.1111/j.1600-0536.1990.tb05168.x.
In the last 3 years, we have studied 10 patients with allergic reactions to topical ketoprofen. We have investigated the sensitization and irritant potential of the drug and the possibility of cross-reactivity with other aryl-propionic non-steroidal anti-inflammatory drugs (ibuproxam, ibuprofen, naproxen, fenoprofen, flubiprofen and tiaprofenic acid). 2 of our patients had contact dermatitis, and the other 8 photocontact dermatitis. One of our patients showed cross-reactivity between ketoprofen and ibuproxam on patch testing. In the photopatch tests, we observed cross-reactivity between ketoprofen and tiaprofenic acid in 2 patients, and cross-reaction between ketoprofen and ibuproxam and flurbiprofen in another case. Experimental studies, including human maximization and photomaximization tests, performed in 20 healthy volunteers, showed a complete absence of sensitization, 3 volunteers showed a marked irritant reaction to ketoprofen (20% pet.) during either maximization (2 cases) or photomaximization (1 case) tests. Although ketoprofen appears not to be a sensitizing agent in human volunteers, the fact that photosensitization to this drug seems to be quite common after topical use suggests that there are some local or individual factors, at present unknown, facilitating the development of allergy.
在过去3年里，我们研究了10例对局部用酮洛芬过敏的患者。我们调查了该药物的致敏和刺激潜力，以及与其他芳基丙酸类非甾体抗炎药（异丁苯丙酸、布洛芬、萘普生、非诺洛芬、氟比洛芬和噻洛芬酸）交叉反应的可能性。我们的患者中有2例患接触性皮炎，另外8例患光接触性皮炎。我们的1例患者在斑贴试验中显示酮洛芬与异丁苯丙酸之间存在交叉反应。在光斑贴试验中，我们观察到2例患者的酮洛芬与噻洛芬酸之间存在交叉反应，在另一例中，酮洛芬与异丁苯丙酸和氟比洛芬之间存在交叉反应。在20名健康志愿者身上进行的实验研究，包括人体最大剂量试验和光最大剂量试验，结果显示完全没有致敏现象，3名志愿者在最大剂量试验（2例）或光最大剂量试验（1例）期间对酮洛芬（20%凡士林制剂）表现出明显的刺激反应。虽然酮洛芬在人体志愿者中似乎不是致敏剂，但局部使用该药物后光过敏现象似乎相当常见，这一事实表明存在一些目前尚不清楚的局部或个体因素，促进了过敏反应的发生。
