病态肥胖患者体内循环脂肪细胞因子与心血管危险因素及人体测量参数的关系。

Circulating adipocytokines in morbid obese patients, relation with cardiovascular risk factors and anthropometric parameters.

作者信息

de Luis D A, González Sagrado M, Conde R, Aller R, Izaola O, Castro M J

机构信息

Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School, University of Valladolid, Valladolid, Spain.

出版信息

Nutr Hosp. 2011 Jan-Feb;26(1):91-6.

PMID:21519734

Abstract

BACKGROUND

Obesity and insulin resistance are associated with cardiovascular risk factors, including adipocytokines. The aim of the present study was to explore the relation of circulating adipocytokines with cardiovascular risk and anthropometric parameters in morbid obese patients.

SUBJECTS

A population of 65 morbid obese patients was analyzed in a prospective way. A biochemical, anthropometric and dietary evaluation was realized.

RESULTS

In the multivariate analysis with resistin as dependent variable, the BMI remained in the model (F = 16.6; p < 0.05), with an increase of 0.23 (CI 95%: 0.06-0.41) ng/ml with each point of BMI. In a second model with adiponectin as dependent variable, the age remained in the model (F = 4.46; p < 0.05), with an increase of 3.62 (CI 95%: 0.05-7.21) ng/ml with each year. In the third model with interleukin 6 as dependent variable, the HOMA, CRP and weight remained in the model (F = 8.8; p < 0.01), with an increase of 0.26 (CI 95%: 0.05-0.47) pg/ml with each point of HOMA, an increase of 0.43 (CI 95%: 0.10-0.76) pg/ml with each 1 mg/dl of CRP and an increase of 0.13 (CI 95%: 0.05-0.21) pg/ml with each kg of weight. In the fourth model with TNF-alpha as dependent variable, resistin, IL-6 and weight remained in the model (F = 5.2; p < 0.01), with an increase of 1.49 (CI 95%: 0.46-2.53) pg/ml with each point of resistin, an increase of 1.20 (CI 95%: 0.38-2.10) pg/ml with each 1 pg/dl of IL-6 and an increase of 0.27 (CI 95%: 0.04-0.51) pg/ml with each kg of weight. In the fifth model with leptin as dependent variable, BMI and TNF-alpha remained in the model (F = 4.1; p < 0.01), with an increase of 10.35 (CI 95%: 4.10-21.12) ng/ml with each point of BMI and a decrease of 10.16 (CI 95%: -20.37-0.76) pg/ml with each 1 pg/dl of TNF-alpha.

CONCLUSION

Circulating adipocytokine concentrations are associated with different cardiovascular risk factors and anthropometric variables in morbid obese patients.

摘要

背景

肥胖和胰岛素抵抗与心血管危险因素相关，包括脂肪细胞因子。本研究的目的是探讨病态肥胖患者循环脂肪细胞因子与心血管风险及人体测量参数之间的关系。

研究对象

对65例病态肥胖患者进行了前瞻性分析。进行了生化、人体测量和饮食评估。

结果

在以抵抗素为因变量的多变量分析中，BMI保留在模型中（F = 16.6；p < 0.05），BMI每增加1个单位，抵抗素增加0.23（95%置信区间：0.06 - 0.41）ng/ml。在以脂联素为因变量的第二个模型中，年龄保留在模型中（F = 4.46；p < 0.05），年龄每增加1岁，脂联素增加3.62（95%置信区间：0.05 - 7.21）ng/ml。在以白细胞介素6为因变量的第三个模型中，HOMA、CRP和体重保留在模型中（F = 8.8；p < 0.01），HOMA每增加1个单位，白细胞介素6增加0.26（95%置信区间：0.05 - 0.47）pg/ml，CRP每增加1mg/dl，白细胞介素6增加0.43（95%置信区间：0.10 - 0.76）pg/ml，体重每增加1kg，白细胞介素6增加0.13（95%置信区间：0.05 - 0.21）pg/ml。在以肿瘤坏死因子-α为因变量的第四个模型中，抵抗素、白细胞介素6和体重保留在模型中（F = 5.2；p < 0.01），抵抗素每增加1个单位，肿瘤坏死因子-α增加1.49（95%置信区间：0.46 - 2.53）pg/ml，白细胞介素6每增加1pg/dl，肿瘤坏死因子-α增加1.20（95%置信区间：0.38 - 2.10）pg/ml，体重每增加1kg，肿瘤坏死因子-α增加0.27（95%置信区间：0.04 - 0.51）pg/ml。在以瘦素为因变量的第五个模型中，BMI和肿瘤坏死因子-α保留在模型中（F = 4.1；p < 0.01），BMI每增加1个单位，瘦素增加10.35（95%置信区间：4.