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自闭症谱系障碍儿童的年龄为 5 岁时的弟弟妹妹的神经认知和行为结果。

Neurocognitive and behavioral outcomes of younger siblings of children with autism spectrum disorder at age five.

机构信息

Department of Pediatrics, Vanderbilt Kennedy Center/TRIAD, Vanderbilt University, 230 Appleton Pl., Nashville, TN 37203, USA.

出版信息

J Autism Dev Disord. 2012 Mar;42(3):409-18. doi: 10.1007/s10803-011-1263-4.

Abstract

Later-born siblings of children with Autism Spectrum Disorders (ASD) are at increased risk for ASD as well as qualitatively similar traits not meeting clinical cutoffs for the disorder. This study examined age five neurocognitive and behavioral outcomes of 39 younger siblings of children with ASD (Sibs-ASD) and 22 younger siblings of typically developing children (Sibs-TD) previously assessed in a longitudinal investigation starting in the second year of life. There were few group differences between Sibs-TD and Sibs-ASD on global measures of IQ, language, or behavior problems. Sibs-ASD did show vulnerabilities on measures of executive functioning, social cognition, and repetitive behaviors. These results highlight the importance of following sibling risk groups over an extended time period and employing measures targeting broader aspects of development.

摘要

自闭症谱系障碍(ASD)儿童的晚生兄弟姐妹患 ASD 以及未达到该障碍临床标准的定性相似特征的风险增加。本研究检查了 39 名 ASD 儿童(Sibs-ASD)的年幼兄弟姐妹和 22 名发育正常儿童(Sibs-TD)的 5 岁神经认知和行为结果,这些儿童之前在一项从生命第二年开始的纵向研究中进行了评估。在 IQ、语言或行为问题的全球衡量标准上,Sibs-TD 和 Sibs-ASD 之间几乎没有差异。Sibs-ASD 在执行功能、社会认知和重复行为方面确实存在脆弱性。这些结果强调了在较长时间内跟踪兄弟姐妹风险群体并采用针对更广泛发展方面的措施的重要性。

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