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预测自闭症谱系障碍患儿同胞弟妹的社交障碍及自闭症谱系障碍诊断情况。

Predicting social impairment and ASD diagnosis in younger siblings of children with autism spectrum disorder.

作者信息

Yoder Paul, Stone Wendy L, Walden Tedra, Malesa Elizabeth

机构信息

Special Education Department, Vanderbilt University, Nashville, TN 37203, USA.

出版信息

J Autism Dev Disord. 2009 Oct;39(10):1381-91. doi: 10.1007/s10803-009-0753-0. Epub 2009 May 16.

Abstract

Later-born siblings of children with autism spectrum disorder (Sibs-ASD) are at elevated risk for social impairments. Two putative predictors of later social impairment-measures of responding to joint attention and weighted triadic communication-were examined in a sample of 43 Sibs-ASD who were followed from 15 to 34 months of age. Results revealed that initial level of responding to joint attention and growth rate of weighted triadic communication predicted the degree of social impairment at the final measurement period. Additionally, both predictors were associated with later ASD diagnosis. In contrast, unweighted triadic communication, age of entry into the study, and initial language level did not predict later social impairment. The importance of considering social outcome as a continuous variable in prospective studies of Sibs-ASD is discussed.

摘要

患有自闭症谱系障碍儿童的后出生兄弟姐妹(自闭症谱系障碍儿童的兄弟姐妹)存在社交障碍风险增加的情况。在43名从15个月至34个月进行跟踪研究的自闭症谱系障碍儿童的兄弟姐妹样本中,对两个假定的后期社交障碍预测指标——对共同注意的反应测量和加权三元交流——进行了检验。结果显示,对共同注意的初始水平和加权三元交流的增长率可预测最终测量期的社交障碍程度。此外,这两个预测指标均与后期自闭症谱系障碍诊断相关。相比之下,未加权的三元交流、进入研究的年龄和初始语言水平并不能预测后期社交障碍。文中讨论了在自闭症谱系障碍儿童的兄弟姐妹前瞻性研究中,将社交结果视为连续变量的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba3b/4136693/4ea879dbf2ac/nihms613076f1.jpg

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