SK2 通道在小脑浦肯野细胞中的表达和功能。
SK2 channel expression and function in cerebellar Purkinje cells.
机构信息
Laboratoire Physiologie Cellulaire de la Synapse, CNRS, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.
出版信息
J Physiol. 2011 Jul 15;589(Pt 14):3433-40. doi: 10.1113/jphysiol.2011.205823. Epub 2011 Apr 26.
Abstract
Small-conductance calcium-activated K(+) channels (SK channels) regulate the excitability of neurons and their responsiveness to synaptic input patterns. SK channels contribute to the afterhyperpolarization (AHP) following action potential bursts, and curtail excitatory postsynaptic potentials (EPSPs) in neuronal dendrites. Here we review evidence that SK2 channels are expressed in rat cerebellar Purkinje cells during development and throughout adulthood, and play a key role in diverse cellular processes such as the regulation of the spike firing frequency and the modulation of calcium transients in dendritic spines. In Purkinje cells as well as in other types of neurons, SK2 channel plasticity seems to provide an important mechanism allowing these cells to adjust their intrinsic excitability and to alter the probabilities for the induction of synaptic learning correlates, such as long-term potentiation (LTP).
摘要
小电导钙激活钾通道 (SK 通道) 调节神经元的兴奋性及其对突触输入模式的反应性。SK 通道有助于动作电位爆发后的超极化后电位 (AHP)，并抑制神经元树突中的兴奋性突触后电位 (EPSP)。在这里，我们回顾了证据，表明 SK2 通道在发育过程中和成年期都在大鼠小脑浦肯野细胞中表达，并在多种细胞过程中发挥关键作用，如调节尖峰放电频率和调节树突棘中的钙瞬变。在浦肯野细胞以及其他类型的神经元中，SK2 通道可塑性似乎提供了一种重要的机制，使这些细胞能够调整其内在兴奋性，并改变诱导突触学习相关物（如长时程增强 (LTP)）的概率。
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