Jin Tian, Hereld Dale
Chemotaxis Signal Section, Laboratories of Immunogenetics, NIAID, NIH, Rockville, MD 20852, USA.
Eur J Cell Biol. 2006 Sep;85(9-10):905-13. doi: 10.1016/j.ejcb.2006.04.008. Epub 2006 Jun 2.
The discovery in 1947 of directed cell movement in Dictyostelium discoideum quietly gave a birth to a new line of investigation into the molecular basis of chemotaxis. Some 60 years later, D. discoideum continues to be a key model system for the study of eukaryotic chemotaxis as well as an array of other important biological processes. As one of the most influential scientists, Guenther Gerisch has inspired several generations of researchers with his insightful and rigorous approaches applied to this model system. His studies have greatly contributed to current knowledge of many fundamental processes, such as cell-cell adhesion, phagocytosis, endocytosis, cytokinesis, cell signaling and chemotaxis. In this review, we wish to look back at the journey that has led to our current understanding of chemotaxis of eukaryotic cells.
1947年，盘基网柄菌中定向细胞运动的发现悄然开启了对趋化性分子基础的新研究方向。大约60年后，盘基网柄菌仍然是研究真核生物趋化性以及一系列其他重要生物学过程的关键模型系统。作为最具影响力的科学家之一，京特·格里施以其应用于该模型系统的深刻而严谨的方法激励了几代研究人员。他的研究为当前许多基础过程的知识做出了巨大贡献，如细胞间粘附、吞噬作用、胞吞作用、胞质分裂、细胞信号传导和趋化性。在这篇综述中，我们希望回顾一下引领我们目前对真核细胞趋化性理解的历程。
