溶酶体定位对自噬的调控。
Regulation of autophagy by lysosomal positioning.
机构信息
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, UK.
出版信息
Autophagy. 2011 Aug;7(8):927-8. doi: 10.4161/auto.7.8.15862. Epub 2011 Aug 1.
Abstract
The mammalian target of rapamycin (mTOR) is a well-conserved negative regulator of autophagy. Here we review our recent data describing how lysosomal positioning influences and coordinates mTOR activity, autophagosome biogenesis and autophagosome-lysosome fusion. In this way, lysosomal positioning regulates many diverse cellular responses to starvation and subsequent nutrient replenishment.
摘要
哺乳动物雷帕霉素靶蛋白（mTOR）是自噬的一种高度保守的负调控因子。在这里，我们回顾了我们最近的数据，描述了溶酶体定位如何影响和协调 mTOR 活性、自噬体生物发生以及自噬体-溶酶体融合。通过这种方式，溶酶体定位调节了细胞对饥饿和随后营养补充的许多不同反应。
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本文引用的文献
1
Lysosomal positioning coordinates cellular nutrient responses.溶酶体定位协调细胞的营养反应。
Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.
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