Pediatric Hematology/Oncology, McMaster University, Hamilton, Ontario, Canada.
Cancer. 2011 May 15;117(10 Suppl):2245-9. doi: 10.1002/cncr.26052.
Cancer in adolescents and young adults is an important public health issue, because there are approximately 1 million new cases annually. The distribution of diseases in this age group varies geographically, contributing to differences in survival rates. Although an overall survival rate exceeding 80 % has been reported in optimal circumstances, emerging knowledge about distinctions in tumor biology and enhanced clinical accrual to clinical trials should lead to further gains. The challenges of cancer survivorship demand further attention with a particular focus on the quality of life of survivors and amelioration of the long-term complications of treatment. Programs in cancer screening and prevention provide potential for considerable benefits in this age group. A renewed perspective on the adolescent and young adult cohort is required; and, in all of these opportunities for change, there are important roles to be played by advocacy groups internationally.
青少年和青年癌症是一个重要的公共卫生问题，因为每年大约有 100 万新发病例。该年龄段疾病的分布在地理上存在差异，导致生存率的差异。尽管在最佳情况下报告的总生存率超过 80%，但关于肿瘤生物学差异的新知识和对临床试验的更多临床累积，应该会带来进一步的收益。癌症生存挑战需要进一步关注，特别关注幸存者的生活质量和改善治疗的长期并发症。癌症筛查和预防计划为该年龄段提供了潜在的巨大益处。需要对青少年和青年人群重新审视；在所有这些变革机会中，国际倡导团体都可以发挥重要作用。
