Athanassiadou Anna Maria, Patsouris Efstratios, Tsipis Angelos, Gonidi Maria, Athanassiadou Pauline
1st Pathology Laboratory, Cytology Unit, Medical School, University of Athens, Athens, Greece.
Folia Histochem Cytobiol. 2011;49(1):26-33. doi: 10.5603/fhc.2011.0005.
To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified.
探讨生存素（Survivin）和连接黏附分子4（Nectin-4）在乳腺癌中的表达及其预后意义。从140例乳腺癌标本中获取印片涂片，采用免疫细胞化学方法研究Survivin和Nectin-4的表达情况。将结果与包括五年生存率在内的多项临床病理参数进行相关性分析。Survivin染色增强与肿瘤分级增加（p<0.0001）、淋巴结转移增加（p<0.0001）、肿瘤大小增加及生存率降低（p<0.0001）相关。Nectin-4表达升高也与肿瘤分级增加（p<0.0001）、肿瘤大小增加（p<0.0001）及生存率降低（p<0.0001）显著相关。此外，Survivin和Nectin-4染色模式之间存在强相关性（p<0.0001）。然而，在多因素分析中，在我们的研究病例中，Survivin和Nectin-4的表达似乎均对生存无独立影响。我们的研究结果表明，Survivin和Nectin-4表达增加可能提示乳腺癌患者预后较差。这些标志物在乳腺癌预后和治疗中的具体意义仍有待阐明。
