Troussard X, Galateau F, Gaulard P, Reman O, Henni T, Le Couedic J P, Leporrier M
Service Hematologie Clinique, CHU Clémenceau, Caen, France.
Cancer. 1990 Jan 1;65(1):107-11. doi: 10.1002/1097-0142(19900101)65:1<107::aid-cncr2820650122>3.0.co;2-m.
In a patient treated for acute myeloblastic leukemia (AML), we saw an angiocentric and angiodestructive lymphoma that resembled lymphomatoid granulomatosis (LG). The lesions tended to involve extranodal sites such as the lung, the parotid gland, and the skin. The immunologic studies showed that the proliferating lymphoid cells were mature T cells. Furthermore, genotypic studies disclosed a clonal rearrangement of the beta T-cell receptor gene. It is concluded that this case of LG is related to a neoplastic T-cell lymphoproliferative disorder. The relations between LG and the previous AML are discussed.
在一名接受急性髓细胞白血病（AML）治疗的患者中，我们发现了一种血管中心性和血管破坏性淋巴瘤，其类似于淋巴瘤样肉芽肿病（LG）。病变倾向于累及肺、腮腺和皮肤等结外部位。免疫研究表明，增殖的淋巴细胞是成熟T细胞。此外，基因分型研究揭示了β T细胞受体基因的克隆重排。得出的结论是，该例LG与肿瘤性T细胞淋巴增殖性疾病有关。并讨论了LG与先前AML之间的关系。
