National Yang-Ming University, Institute of Biomedical Engineering, No 155, Sec 2, Linong Street, Beitou District, Taipei City 112, Taiwan.
J Biomed Opt. 2011 Apr;16(4):046009. doi: 10.1117/1.3562964.
Dry eye syndrome is a common irritating eye disease. Current clinical diagnostic methods are invasive and uncomfortable for patients. This study developed a custom designed noncontact infrared (IR) thermal image system to measure the spatial and temporal variation of the ocular surface temperature over a 6-second eye-open period. This research defined two parameters: the temperature difference value and the compactness value to represent the temperature change and the irregularity of the temperature distribution on the tear film. Using these two parameters, this study achieved discrimination results for the dry eye and the normal eye groups; the sensitivity is 0.84, the specificity is 0.83, and the receiver operating characteristic area is 0.87. The results suggest that the custom designed IR thermal image system may be used as an effective tool for noncontact detection of dry eye.
干眼症是一种常见的刺激性眼病。目前的临床诊断方法对患者具有侵入性和不舒适性。本研究开发了一种定制的非接触式红外(IR)热像系统,以测量 6 秒睁眼期间眼表面温度的空间和时间变化。本研究定义了两个参数:温差值和紧凑度值,以表示泪膜上的温度变化和温度分布的不规则性。使用这两个参数,本研究实现了对干眼症和正常眼组的区分结果;灵敏度为 0.84,特异性为 0.83,受试者工作特征区为 0.87。结果表明,定制的 IR 热像系统可能可用作干眼症非接触检测的有效工具。