Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Montréal QC H2X 1P1, Canada.
Immunobiology. 2012 May;217(5):521-32. doi: 10.1016/j.imbio.2011.03.010. Epub 2011 Apr 7.
CD40 Ligand (CD40L), a member of the TNF family, was initially thought to be solely implicated in thymus-dependent humoral responses. However, work by several groups showed that CD40L plays a more global role in various systems. Recent evidence has outlined an important role for CD40L in the physiopathology of the vascular system. Indeed, by interacting with its principal receptor, CD40, or with the recently identified receptors, namely αIIbβ3, α5β1, and Mac-1 integrins, CD40L displayed many biological functions in different types of vascular cells. In addition, the CD40L system was demonstrated a major player in the pathology of vascular diseases, such as atherosclerosis and restenosis. This review outlines the expression pattern and the functional properties of CD40L and its receptors at different cellular levels in the vascular system. In addition, we thoroughly describe evidence showing the implication of CD40L interactions in atherosclerosis, restenosis, and their associated clinical complications.
CD40 配体（CD40L）是 TNF 家族的成员，最初被认为仅参与胸腺依赖性体液反应。然而，几个研究小组的工作表明，CD40L 在各种系统中发挥着更广泛的作用。最近的证据表明，CD40L 在血管系统的生理病理中起着重要作用。事实上，通过与其主要受体 CD40 相互作用，或与最近发现的受体，即 αIIbβ3、α5β1 和 Mac-1 整合素相互作用，CD40L 在不同类型的血管细胞中表现出许多生物学功能。此外，CD40L 系统被证明是血管疾病（如动脉粥样硬化和再狭窄）病理的主要参与者。这篇综述概述了 CD40L 及其受体在血管系统不同细胞水平上的表达模式和功能特性。此外，我们还详细描述了证据表明 CD40L 相互作用在动脉粥样硬化、再狭窄及其相关临床并发症中的作用。
