Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Diab Vasc Dis Res. 2013 Mar;10(2):115-22. doi: 10.1177/1479164112455817. Epub 2012 Sep 10.
Numerous epidemiological studies have consistently demonstrated the strong association between type 2 diabetes mellitus (T2DM) and an increased risk to develop cardiovascular disease. The pathogenesis of T2DM and its complications are characterized by pancreatic, adipose tissue and vascular inflammation. CD40 and CD40L, members of the tumour necrosis factor (receptor) TNF(R) family, are well known for their role in immunity and inflammation. Here we give an overview on the role of CD40-CD40L interactions in the pathogenesis of T2DM with a special focus on pancreatic, adipose tissue and vascular inflammation. In addition, we explore the role of soluble CD40L (sCD40L) as a potential biomarker for the development of cardiovascular disease in T2DM subjects. Finally, the therapeutic potential of CD40-CD40L inhibition in T2DM is highlighted.
许多流行病学研究都一致表明，2 型糖尿病（T2DM）与心血管疾病风险增加之间存在很强的关联。T2DM 及其并发症的发病机制以胰腺、脂肪组织和血管炎症为特征。CD40 和 CD40L 是肿瘤坏死因子（受体）TNF（R）家族的成员，它们在免疫和炎症中的作用是众所周知的。在这里，我们概述了 CD40-CD40L 相互作用在 T2DM 发病机制中的作用，特别关注胰腺、脂肪组织和血管炎症。此外，我们还探讨了可溶性 CD40L（sCD40L）作为 T2DM 患者心血管疾病发展的潜在生物标志物的作用。最后，强调了 CD40-CD40L 抑制在 T2DM 中的治疗潜力。
