Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Biochem Biophys Res Commun. 2011 May 13;408(3):500-4. doi: 10.1016/j.bbrc.2011.04.082. Epub 2011 Apr 21.
Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.
神经元中缺少 tau 蛋白的表达会导致少数基因的表达发生变化。然而，tau 如何调节基因表达的机制尚不清楚。在这里，我们发现 tau 的存在可以改变钙调蛋白的亚细胞定位，钙调蛋白是一种可以位于细胞质或细胞核中的蛋白质。核钙调蛋白与共转录因子结合，调节钙结合蛋白等基因的表达。在这项工作中，我们发现与不含 tau 的神经元相比，含有 tau 的神经元中细胞质内的钙调蛋白比例更高，并且细胞质内钙调蛋白的增加与钙结合蛋白的表达增加相关。
