National Institute of Complementary Medicine (NICM) Collaborative Centre for Neurocognition, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Melbourne, Victoria 3122, Australia.
Neurobiol Aging. 2012 Apr;33(4):824.e1-3. doi: 10.1016/j.neurobiolaging.2011.03.019. Epub 2011 May 4.
The omega-3 fatty acid docosahexaenoic acid (DHA) is essential for nervous system and retinal development and there is evidence to suggest that DHA deficiencies increase with normal aging. A triple-blind placebo-controlled randomized repeated-measures trial was conducted with 74 healthy participants, aged 45-77 years. Cognitive and visual acuity measures and plasma levels of DHA were determined at baseline and after 90 days of administration of either HiDHA(®) (Clover Corp., Sydney, NSW, Australia: 1000 mg of tuna oil; comprising 252 mg DHA, 60 mg EPA and 10 mg vitamin E) or placebo (1000 mg soybean oil). Ninety days of DHA supplementation was found to significantly raise both plasma DHA and total ω-3 plasma levels in the treatment group, as well as significantly lower total ω-6 levels. However, no significant effects of DHA supplementation on cognitive functioning were found. For participants with corrected vision, the group receiving DHA were found to have significantly better right eye visual acuity posttreatment in comparison with the placebo group (F(1,22) = 7.651; p = 0.011; partial η(2) = 0.258).
ω-3 脂肪酸二十二碳六烯酸（DHA）对神经系统和视网膜发育至关重要，有证据表明 DHA 缺乏随着正常衰老而增加。对 74 名年龄在 45-77 岁的健康参与者进行了一项三盲、安慰剂对照、随机重复测量试验。在开始服用 HiDHA(®)（Clover Corp.，悉尼，新南威尔士州，澳大利亚：1000 毫克金枪鱼油；包含 252 毫克 DHA、60 毫克 EPA 和 10 毫克维生素 E）或安慰剂（1000 毫克大豆油）90 天后，测定认知和视力以及 DHA 的血浆水平。结果发现，DHA 补充 90 天可显著提高治疗组的血浆 DHA 和总 ω-3 血浆水平，并显著降低总 ω-6 水平。然而，DHA 补充对认知功能没有显著影响。对于校正视力的参与者，与安慰剂组相比，服用 DHA 的组在治疗后右眼视力明显更好（F(1,22) = 7.651；p = 0.011；部分 η(2) = 0.258）。
