Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Biol Psychol. 2012 Jan;89(1):183-90. doi: 10.1016/j.biopsycho.2011.10.006. Epub 2011 Oct 19.
A number of recent studies have assessed the impact of dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) on behavioral outcomes; however, very little attention has been given to their impact upon brain function in physiological terms. Sixty-five healthy adults aged 18-29yrs took part in this double-blind, placebo-controlled study assessing the effects of 12 weeks daily dietary supplementation with docosahexaenoic acid-rich fish oil (1g, 2g) or placebo (olive oil). Relative changes in the concentration of oxyhemoglobin and deoxyhemoglobin were assessed in the prefrontal cortex using near-infrared spectroscopy during performance of nine computerized cognitive tasks. Supplementation with both doses of fish oil, in comparison with placebo, resulted in significantly increased concentrations of oxyhemoglobin and total levels of hemoglobin, indicative of increased cerebral blood flow, during the cognitive tasks. Changes in hemodynamic response to tasks were not accompanied by consistent changes in cognitive performance.
一些最近的研究评估了饮食中欧米伽-3 多不饱和脂肪酸（n-3PUFAs）对行为结果的影响；然而，很少有人关注它们对生理意义上的大脑功能的影响。65 名年龄在 18-29 岁的健康成年人参与了这项双盲、安慰剂对照研究，评估了 12 周每日食用富含二十二碳六烯酸的鱼油（1 克、2 克）或安慰剂（橄榄油）对大脑功能的影响。在进行九项计算机认知任务时，使用近红外光谱技术评估前额叶皮层中氧合血红蛋白和脱氧血红蛋白浓度的相对变化。与安慰剂相比，两种剂量的鱼油补充剂都导致了认知任务中氧合血红蛋白和血红蛋白总量浓度的显著增加，表明大脑血液流量增加。任务的血液动力学反应的变化并没有伴随着认知表现的一致变化。
