Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA.
Neurobiol Aging. 2012 Aug;33(8):1758-68. doi: 10.1016/j.neurobiolaging.2011.03.017. Epub 2011 May 4.
There is growing interest in the influence of early-life development on clinical manifestations of late-life diseases. Latent variable modeling was used to investigate how maximal brain volume (measured by intracranial volume [ICV]) and current brain volumes uniquely contribute to domain-specific cognitive performance in a group of 401 cognitively and ethnically diverse older adults. Individual effects of volumetric magnetic resonance imaging (MRI) measures including ICV were examined as predictors of episodic memory, semantic memory, spatial ability, and executive function. Total brain matter volume related to all cognitive domains; hippocampal volume was associated primarily with episodic memory; white matter hyperintensity volume was related to executive function and episodic memory. Maximal brain size as measured by ICV was related to semantic memory, executive function, and spatial ability independent of current brain volumes (ps < 0.01). Relationships between magnetic resonance imaging (MRI) variables and cognition did not differ substantially across groups defined by ethnicity, gender, and with minor exceptions, clinical diagnosis. Results suggest maximal brain development and measures of brain injury/atrophy jointly contribute to cognitive function in older people.
人们对生命早期发育对晚年疾病临床表现的影响越来越感兴趣。本研究采用潜变量建模方法，调查了在 401 名认知和种族多样化的老年人中，最大脑容量（通过颅内体积[ICV]测量）和当前脑容量如何独特地影响特定领域的认知表现。研究还检查了磁共振成像（MRI）测量的个体效应，包括 ICV，作为对情景记忆、语义记忆、空间能力和执行功能的预测因子。总脑物质体积与所有认知领域相关；海马体体积主要与情景记忆相关；脑白质高信号体积与执行功能和情景记忆相关。ICV 测量的最大脑尺寸与语义记忆、执行功能和空间能力相关，与当前脑容量无关（p<0.01）。MRI 变量与认知之间的关系在按种族、性别以及少数例外的临床诊断定义的组之间没有显著差异。结果表明，最大脑发育和脑损伤/萎缩测量共同影响老年人的认知功能。
