Dementia Research Centre, Institute of Neurology, University College London, London, UK.
J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1274-8. doi: 10.1136/jnnp.2010.235473. Epub 2011 Apr 28.
Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined.
with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the significance and basis for these symptoms have not been elucidated.
43 patients with a diagnosis of SemD attending a specialist cognitive disorders clinic were retrospectively studied. 14 patients (32% of the cohort) reported at least moderately severe chronic auditory symptoms: seven had tinnitus and a further seven had hyperacusis, and all had brain MRI while symptomatic. MRI data from SemD patients with and without auditory symptoms were compared using voxel based morphometry in order to identify neuroanatomical associations of tinnitus and hyperacusis.
Compared with SemD patients with no history of auditory symptoms, patients with tinnitus or hyperacusis had relative preservation of grey matter in the posterior superior temporal lobe and reduced grey matter in the orbitofrontal cortex and medial geniculate nucleus.
Tinnitus and hyperacusis may be a significant issue in SemD. Neuroanatomical evidence in SemD supports previous work implicating a distributed cortico-subcortical auditory and limbic network in the pathogenesis of these abnormal auditory percepts.
耳鸣和听觉过敏是普通人群中听觉感知过度的常见症状；然而，其解剖学基础和疾病关联仍在不断确定。
语义性痴呆（SemD）患者常报告有耳鸣和听觉过敏，但这些症状的意义和基础尚未阐明。
对 43 名在专门认知障碍诊所就诊的 SemD 患者进行回顾性研究。14 名患者（队列的 32%）报告了至少中度严重的慢性听觉症状：7 名患者有耳鸣，另有 7 名患者有听觉过敏，所有患者在有症状时均进行了脑部 MRI。使用基于体素的形态测量法比较有和无听觉症状的 SemD 患者的 MRI 数据，以确定耳鸣和听觉过敏的神经解剖学关联。
与无听觉症状史的 SemD 患者相比，有耳鸣或听觉过敏的患者在后上颞叶的灰质相对保留，而眶额皮质和内侧膝状体的灰质减少。
耳鸣和听觉过敏可能是 SemD 的一个重要问题。SemD 的神经解剖学证据支持先前的工作，即提示分布式皮质下听觉和边缘网络参与这些异常听觉知觉的发病机制。
