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家蚕血液蛋白的抗李斯特菌活性。

Anti-Listeria activities of Galleria mellonella hemolymph proteins.

机构信息

Institute of Phytopathology and Applied Zoology, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.

出版信息

Appl Environ Microbiol. 2011 Jun;77(12):4237-40. doi: 10.1128/AEM.02435-10. Epub 2011 Apr 29.

DOI:10.1128/AEM.02435-10
PMID:21531838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3131625/
Abstract

We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria.

摘要

我们报告了使用模式宿主家蚕的抗菌血淋巴蛋白作为各种李斯特菌菌株的抑制剂，为抗李斯特菌治疗提供了新的来源。我们还表明，在哺乳动物模型中已知介导李斯特菌抗菌耐药性的特定与毒力相关基因在 Galleria 中也具有类似的功能。

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本文引用的文献

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Complete genome sequence of Listeria seeligeri, a nonpathogenic member of the genus Listeria.李斯特菌属非致病菌李斯特氏菌的完整基因组序列。
J Bacteriol. 2010 Mar;192(5):1473-4. doi: 10.1128/JB.01415-09. Epub 2010 Jan 8.
2
Galleria mellonella as a model system for studying Listeria pathogenesis.大蜡螟（Galleria mellonella）作为研究李斯特菌发病机制的模型系统。
Appl Environ Microbiol. 2010 Jan;76(1):310-7. doi: 10.1128/AEM.01301-09. Epub 2009 Nov 6.
3
The dlt operon of Bacillus cereus is required for resistance to cationic antimicrobial peptides and for virulence in insects.蜡样芽孢杆菌的dlt操纵子对于抵抗阳离子抗菌肽以及在昆虫中的致病性是必需的。
J Bacteriol. 2009 Nov;191(22):7063-73. doi: 10.1128/JB.00892-09. Epub 2009 Sep 18.
4
Comparative analysis on antibiotic resistance characteristics of Listeria spp. and Enterococcus spp. isolated from laying hens and eggs in conventional and organic keeping systems in Bavaria, Germany.德国巴伐利亚州常规和有机饲养系统中产蛋鸡和鸡蛋中分离的李斯特菌和肠球菌的抗生素耐药特性比较分析。
Zoonoses Public Health. 2010 May;57(3):171-80. doi: 10.1111/j.1863-2378.2008.01229.x.
5
Comparative antimicrobial susceptibility of Listeria monocytogenes, L. innocua, and L. welshimeri.单核细胞增生李斯特菌、无害李斯特菌和威尔斯李斯特菌的抗菌药物敏感性比较。
Microb Drug Resist. 2009 Mar;15(1):27-32. doi: 10.1089/mdr.2009.0863.
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Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis.自动、手动及微波辅助固相肽合成的进展
Curr Opin Drug Discov Devel. 2008 Nov;11(6):762-70.
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Pathogenomics of Listeria spp.李斯特菌属的病原基因组学
Int J Med Microbiol. 2007 Nov;297(7-8):541-57. doi: 10.1016/j.ijmm.2007.03.016. Epub 2007 May 7.
8
Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.从大蜡螟免疫血淋巴中纯化和鉴定八种肽
Peptides. 2007 Mar;28(3):533-46. doi: 10.1016/j.peptides.2006.11.010. Epub 2006 Dec 27.
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The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenes.MprF蛋白是李斯特菌细胞膜中磷脂赖氨酰化所必需的，它赋予单核细胞增生李斯特菌对阳离子抗菌肽（CAMP）的抗性。
Mol Microbiol. 2006 Dec;62(5):1325-39. doi: 10.1111/j.1365-2958.2006.05452.x. Epub 2006 Oct 17.
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Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes.韦氏李斯特菌的全基因组序列揭示了与无害李斯特菌相比，其在基因组缩减方面与产单核细胞李斯特菌的共同步骤。
J Bacteriol. 2006 Nov;188(21):7405-15. doi: 10.1128/JB.00758-06. Epub 2006 Aug 25.