Tamulevicus Amy M, Harkin Kenneth, Janardhan Kyathanahalli, Debey Brad M
Clinical Sciences, Small Animal Medicine, Kansas State University, Manhattan, KS, USA.
J Am Anim Hosp Assoc. 2011 May-Jun;47(3):e36-41. doi: 10.5326/JAAHA-MS-5517. Epub 2011 Apr 15.
A 4 yr old, spayed female domestic shorthair was referred with a 2 mo history of weight loss, anorexia, and diarrhea. Skin fragility was noted on presentation and a large skin tear measuring 5 cm × 5 cm was obvious over the dorsal cervical region. The patient was previously treated with short-term prednisone that was discontinued 6 wk before presentation. Initial diagnostics (complete blood count and biochemistry) did not indicate an endocrine disorder, the most common cause of acquired feline skin fragility. Necropsy revealed diffuse histoplasmosis (most significantly affecting the skin), epidermal atrophy, dermal collagen separation, and infiltration in the dermis and subcutis by inflammatory cells containing yeast organisms consistent with Histoplasma spp. Infiltrative fungal infection should be considered as a potential cause of acquired feline skin fragility.
一只4岁已绝育的雌性家养短毛猫因体重减轻、厌食和腹泻2个月的病史前来就诊。就诊时发现皮肤脆弱，在颈背部有一处明显的5厘米×5厘米的大皮肤撕裂伤。该患者此前接受过短期泼尼松治疗，在就诊前6周停药。初步诊断（全血细胞计数和生化检查）未显示内分泌紊乱，而内分泌紊乱是获得性猫皮肤脆弱最常见的原因。尸检显示弥漫性组织胞浆菌病（对皮肤影响最为显著）、表皮萎缩、真皮胶原分离，以及真皮和皮下组织中有含有与组织胞浆菌属一致的酵母样生物体的炎性细胞浸润。浸润性真菌感染应被视为获得性猫皮肤脆弱的潜在原因。
