衰老的海马体：运动、抑郁和 BDNF 之间的相互作用。

The aging hippocampus: interactions between exercise, depression, and BDNF.

机构信息

Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Neuroscientist. 2012 Feb;18(1):82-97. doi: 10.1177/1073858410397054. Epub 2011 Apr 29.

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy.

中老年期与海马体萎缩和功能障碍的增加有关。尽管海马体在晚年恶化有多种途径，但作者讨论了以下证据：脑源性神经营养因子（BDNF）基因中的单核苷酸多态性以及 BDNF 蛋白或受体表达随年龄的变化，可能导致海马体萎缩。作者得出结论，很少有研究测试 BDNF 是否介导与年龄相关的海马体萎缩和记忆障碍。然而，有强有力的证据表明，BDNF 的减少与与年龄相关的海马体功能障碍、记忆障碍和抑郁风险增加有关，而通过有氧运动增加 BDNF 似乎可以改善海马体萎缩、改善记忆功能和减少抑郁。重要的是，BDNF 与海马体功能障碍之间最一致的关联来自于对啮齿动物的 BDNF 蛋白表达和人类血清和血浆中 BDNF 浓度的研究。目前的研究表明，BDNF val66met 多态性与中老年期的海马体萎缩相关性较弱。这些结论与与年龄相关的记忆障碍和预防海马体萎缩有关。