Saito Mitsuru
Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan.
Clin Calcium. 2012 Sep;22(9):1323-32.
Diabetes deteriorate bone material properties. Not only hyperglycemia, but also oxidative stress induce the reduction in enzymatic beneficial cross-links and the accumulation of disadvantageous non-enzymatic cross-linking advanced glycation end products (AGEs) such as pentosidine in bone. In this review, I describe the mechanism of low bone quality in diabetes.
糖尿病会使骨材料特性恶化。不仅高血糖，氧化应激也会导致骨中有益酶促交联减少，以及诸如戊糖苷等有害非酶促交联晚期糖基化终产物（AGEs）的积累。在这篇综述中，我描述了糖尿病患者骨质量低下的机制。
